The San Francisco 49ers can sweep the season series against the Seattle Seahawks for the first time since 2011 when the two NFC West rivals faced off in Thursday Night Football at Lumen Field. In Week 2, the 49ers eliminated the Seahawks, 27-7, behind a dominating defensive effort. San Francisco (9-4) would clinch the NFC West title with a victory over TNF. Meanwhile, Seattle (7-6) is in a dogfight for the third and final wildcard spot in the NFC playoff picture. The Seahawks enter Thursday just behind the Commanders and Giants (both 7-5-1) for the final playoff spot.
Kickoff from Lumen Field is scheduled for 8:15 p.m. ET. San Francisco is a three-point favorite in Caesars Sportsbook’s latest 49ers vs. Seahawks odds, while the over/under for total runs scored is 43. NFL betting tips from SportsLine’s advanced computer model.
The model, which simulates every NFL game 10,000 times, has grown more than $7,000 for players to $100 on top NFL picks since its inception. Model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on NFL top picks that dates back to the 2017 season. Model is also a sizzling 21-5 on direct picks of the NFL over the past two weeks.
The model has ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.
Now, the model has set her sights on the 49ers against the Seahawks and has just locked down her Thursday Night Football picks and predictions. You can head over to SportsLine now to see the model choices. Here are several NFL odds and betting lines for the Seahawks vs. 49ers:
- Difference 49ers vs. Seahawks: San Francisco -3
- 49ers vs. Seahawks over/under: 43 points
- 49ers money line vs. Seahawks: San Francisco -190, Seattle +158
- SF: 49ers are 2-8-1 ATS in their last 11 games in Seattle
- SEA: Seahawks are 8-2-2 ATS in their last 12 games on Thursday
- 49ers vs. Seahawks picks: See picks here
Featured game | Seattle Seahawks vs. San Francisco 49ers
Why the 49ers can cover
San Francisco has arguably the best defense in the league. Led by relentless forward Joey Bosa, the 49ers lead the league in both defense (15.2 points per game) and total defense (286.8 yards per game). The 15.2 points per game average is the second best of any team since the start of the 2014 season, behind only the 2019 Patriots (14.1). Bosa is tied for the NFL lead in sacks (14.5) and has at least one sack in six of his last seven games.
Additionally, running back Christian McCaffrey has found his groove with San Francisco. Over the past six games, the former Panthers star has racked up 680 yards from scrimmage and scored six touchdowns. Last week, he had his best game since moving to the 49ers, with 119 rushing yards and two scrimmage touchdowns. See which team to choose here.
Why the Seahawks can cover
Seattle is sixth after finishing in the middle of the pack last season, and quarterback Geno Smith was a big reason for the improvement. The Seahawks are averaging 26.3 points, with Smith serving as the starting quarterback for the first time since 2014 with the New York Jets. The 32-year-old ranks third in the league with 106.8 passers, fourth with 25 touchdowns and sixth with 3,433 passing yards, the latter two being career highs and the first passing. be a personal best.
Smith has one of the best receiving duos to work with in Tyler Lockett and DK Metcalf, both of whom are on pace in 1,000-yard seasons. Lockett, aiming for his fourth straight 1,000-yard campaign, leads Seattle with 896 yards on 71 receptions, while Metcalf has a team-best 72 catches for 869 yards. Lockett, 30, who is six years older, had one touchdown pass in a franchise-record six-game streak and leads the club with eight goals scored, while Metcalf has six. See which team to choose here.
How to make 49ers vs. Seahawks picks on TNF
SportsLine’s model looks at total points, calling for a combined 44 points. The model also indicates that one side of the gap hits in more than 50% of the simulations. You can only see the model’s TNF picks on SportsLine.
So who wins the Seahawks against the 49ers on Thursday Night Football? And which side of the gap hits more than 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. 49ers split you should jump to, all from the pattern on a 157-113 roll on NFL picks, and find out.
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